The oxycodone in OXYCONTIN might induce spasm with the sphincter of Oddi. Opioids may well induce boosts in the serum amylase. Routinely Consider patients with biliary tract disease, such as acute pancreatitis, for worsening indications.If the decision is built to prescribe a benzodiazepine or other CNS depressant concomitantly with an opioid analg